Journal: Microbial Cell Factories
Article Title: Probiotic spore-based antigen delivery: a novel oral vaccine strategy against Vibrio infections in aquaculture
doi: 10.1186/s12934-025-02725-w
Figure Lengend Snippet: Kaplan-Meier survival curves of Medaka fish larvae challenged with Vibrio harveyi 1173, 48 h post-vaccination. Larvae were vaccinated with spores from MV30 alone (Spores), spores displaying the OmpK 21/260 (Spores + OmpK) or free OmpK 21/260 (OmpK) (A) or spores displaying the Hsp33 (Spores + Hsp33), or free Hsp33 (Hsp33) (B) . Non-vaccinated larvae exposed to the pathogen (Vibrio) and non-challenged larvae (Control) served as positive and negative control groups, respectively. Significant differences between groups were assessed using the log-rank test as indicated with asterisks: * = p < 0.05; ** = p < 0.005; *** = p < 0.0005; ****= p < 0.00005. ns = not statistically significant
Article Snippet: Genes coding for these two antigens were identified in the genome of V. harveyi 1173, a virulent strain isolated from Solea solea with splenomegaly (Methods) and characterized by an Average Nucleotide Identity (ANI) value of 98.73% when compared with the reference strain V. harveyi ATCC 33,843.
Techniques: Control, Negative Control